venture-capital

Logan’s List of Entrepreneurship Funding/Mentorship Resources


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After compiling these resources for my personal reference, I realized that others may benefit from them as well. As a person of collaborative spirit, I decided to post them here! Although these are focused on early-stage biotech entrepreneurship, many of the resources should also have broader applicability. I should note that some of the items listed may exist transiently, so parts of this compilation might eventually end up out-of-date. I hope that you find this list helpful for your own adventures!

Accelerators/Incubators

1517’s Flux Capacitor program

  • Part of the 1517 Fund. Offers up to $100K in funding for launching tech companies (including biotech).
  • Emphasizes escape from issues with academia and emphasizes sci-fi-like technologies.
  • “You want to hit ‘pause’ on the academic rat race and spend 3 months on first-principles exploration of either applied, practical problems that can be commercialized within a VC-funded startup in the near-medium term (5 years) or moonshot fundamental science.”
  • Work full-time for 1 summer (presumably some of the $100K may go towards living expenses?)
  • Appears to not require a specific location, though there is a weekend retreat at the beginning of the summer and a dinner at the end of the summer.

Activate Fellowship

  • “Fellows receive a yearly living stipend of $100K, plus travel allowance, health insurance, and relocation. This enables them to focus on their project full-time. Each project also receives $100K in R&D funds at zero cost and access to at least $75K in additional flexible capital.”
  • 2-year program.
  • Also offers intensive mentorship, entrepreneurial education, community support, and research facilities.
  • Eligibility issue for repeat founders: “Must be leading the commercial development of a hardware-based technology innovation for the first time if awarded the fellowship i.e., not a repeat hard tech founder.”
  • Eligibility issue for medical biotech: “Our Fellowship does not currently support innovators developing technologies that only have application in mammalian health. If the underlying technology has the potential to pivot to other, non-healthcare markets and the stage of development is early enough such that market exploration during the fellowship is a key activity, the Activate Fellowship is likely to provide transformative support and it is worth applying. Specifically, if a focus during the fellowship is pursuing FDA approval, Activate is not a good fit. We encourage you to think broadly about the applications and potential impact of your technology and look at other companies we have supported for examples.”
  • Communities in Berkeley, Boston, New York, and Houston. But does not appear to require a specific location.

IndieBio

  • “For the therapeutics track, because only $250K is upfront and the other $1.75 million is over time, we are looking for truly novel platforms and methodologies that need this time to prove their concept.”
  • Requires a co-founder.
  • New York or San Francisco location.

Entrepreneurs First

  • “At the start of the program founders receive an equity free Talent Investment (grant)* to cover living costs.”
  • “During FORM, the goal is to test cofounder partnerships and ideas at pace as you build a company from day one. You’ll be supported by a team of Talent Investors and our global network of advisors, who will challenge your ambitions and develop your vision of success. Throughout FORM, we will push you to obsess about customer development, validating your ideas with customer feedback and traction from the outset. Our goal is to help founders build their initial edge and develop their longer term vision. For those with the biggest ambitions, this will involve getting early traction with US customers and building their vision for that market, which we will support with our network of SF advisors and operators.”
  • “Towards the end of the program teams pitch to our Investment Committee for up to $250,000 in funding per team. This is made up of a $125,000 investment from EF, and the opportunity to receive a further $125,000 investment from EF’s third party investment partner, Transpose Platform*.” If you do not form a company or we choose not to invest at IC, we don’t take any equity and you don’t have to repay the grant. Instead you gain access to a global community of alumni to leverage for future success.
  • It should be noted that the first $125K is “a post-money SAFE* (Simple Agreement for Future Equity) for 8% of your company” and the other potential $125K is an “investment from our partner Transpose Platform via an uncapped MFN (Most Favoured Nation) SAFE.”
  • “At EF, we build technology companies. The majority of individuals who join EF will have a technical background, from self-taught developer through to a Computer Science PhD.” Note that they have also backed biotechnology companies.
  • Spring, Summer, and Winter programs are available.
  • Begins with an 8-week program (FORM) located in San Francisco, New York, London, Paris, or Bangalore. Concludes with a 4-week program where startups settle in San Francisco.

Soma Scholars

  • Part of Soma Capital. Offers a $30K grant (non-dilutive) and an 8-week summer program in San Francisco or New York City where the goal is to “become an expert at something, solve a riddle, write a research paper, prove a math theorem, start a hedge fund, master chess or poker, develop a new drug, launch a space company, design a chip, build a new LLM, or search for aliens!”
  • “We’ll give you a 30k grant, a beautiful office space in SF or NY, access to an elite community, catered dinners and events, and aspirational experiences”.

Nucleate

  • A student-led organization which identifies, educates, connects, and empowers academic biotechnology entrepreneurs to create and run startups. George Church, Tom Kalil, and Pamela Silver are some of the advisors. “Nucleate is a student-led organization that represents the largest global community of bio-innovators”.
  • Website provides the Nucleate Operationalizing Your Therapeutics Spinout Playbook as an educational resource.
  • Offers a six-month activator program that equips academic biotechnology founders with the skills and connections for successful business development.
  • “Activator is a six-month, equity-free cohort program designed for academic biotech founders. Its curriculum has served more than 100 life sciences ventures that have raised over $190 million in venture funding. Participating teams refine their scientific discoveries into biotech venture theses and train under Nucleate’s unparalleled network, rigorous curriculum, funded fellowships, legal support, and highly subsidized perks. Activator culminates in a final pitch showcase before world-renowned judges”.
  • Activator program is free and they do not take equity.
  • Activator program requires projects that have not received any equity funding, but which do have early proof-of-concept data.
  • “Activator takes place in-person in several regions globally. If there is not a Nucleate Chapter in your region, we also offer a Global Virtual Activator. (Ann Arbor, Atlanta, Baltimore, Bay Area, Boston, Canada, Chicago, DC, Denmark, Florida, France UniCA, Germany, Global Virtual, Israel, Los Angeles, New Haven, New York, Philadelphia, RTP, San Diego, Seattle, Switzerland, Texas, Twin City, United Kingdom)”.

Boost VC Bio Residency

  • A program by Boost VC. They emphasize that they are looking for extremely ambitious founders building sci-fi-like technologies. Scientist-founders should have a rebellious spirit and the ability to build businesses in addition to doing science.
  • “The residency includes workshops, office hours, and guest speakers—seasoned Bio founders and top Bio VCs to share journeys and insights to help you move faster.”
  • “The week wraps with a science fair-style showcase happy hour with Bio VCs and networking. Each startup will receive continued access to our housing and office space for 2 weeks after to continue building alongside fellow deep tech founders.”
  • Offers “$500K for 10%” and “Free housing & office space in Silicon Valley” and “Access to a week of hands-on programming designed to help founders craft their business plan and prepare to raise a full pre-seed round”.
  • Gathers the “most ambitious innovators in Bio” in Silicon Valley for an intensive learning and networking experience over the course of 2 weeks.

Neo Residency

  • An accelerator program aimed at startups and student teams. (But one can apply either as a student or as an incorporated startup). It does not require applicants to be students.
  • For startups: “$750K uncapped (YC standard safe). Each founder gets $10K profit share of Neo fund carry. We get participation rights in your next equity round to buy up to 5% total ownership”.
  • Residency provides “3 months at our beautiful SF space. Maximize your productivity and build lasting relationships with founders and mentors at our intensive 2-week Oregon bootcamp. Access to world-class mentors, tech leaders & VCs. Learn from fabled founders and seasoned operators. Meet industry leaders at intimate events and 1:1 sessions. End the program with a Demo Day and bespoke VC intros. OpenAI & Microsoft perks, community, & more.”
  • Neo also offers additional investment opportunities “Pre-seed & seed funding: Contact one of our team members (we prefer warm intros). We lead priced equity rounds or safes with our standard side letter.”
  • At least one member of the founding team must be technical.
  • One can apply as a solo founder or as a team. The program strongly encourages people looking for a cofounder find one before applying.
  • Occurs in person for ~3 months (SF location).

Silicon Valley Fellowship

  • 1-week program which says they make one into a “Silicon Valley insider”.
  • “Get access to a community of experienced alumni and mentors, networking events, and learn first-hand insights from Silicon Valley-based Big Tech professionals, investors, and tech entrepreneurs. A program to get fast-tracked into Silicon Valley ​through workshops, private community and networking events held in and around the cities of the San ​Francisco Bay Area. It’s a deep dive into the expertise of heads of Global tech ​corporations, professors of top world ranked universities, and ​founders of successful companies.”
  • Offers industry-leader talks, visits to companies and universities, networking opportunities, and a Slack community.
  • They also invest small $10K checks into companies through a separate application.

General Funding Opportunities

Boost VC $500K preseed

  • Boost VC offers a $500K investment (unclear as to if this is a SAFE or something else) for early-stage startups, particularly for technical founders who are good at storytelling and possess exceptional determination.
  • “Boost VC is looking for founders with the courage to stand up for what they believe, and the determination to build an enormous company. In order to do this, you must have a unique insight on the universe and have the self confidence to build things that seem impossible to your family/friends/everyone. Only apply if you DARE MIGHTY THINGS! On a GOOD QUEST! We invest $500k to be the first partner in important things!”

Boost VC $50K fellowship

  • Boost VC offers a $50K investment at a $1.5M valuation cap for early-stage startups, particularly for technical founders who are good at storytelling and possess exceptional determination.
  • “Boost VC is proud to introduce the Boost VC Fellowship (an equity based Fellowship), where we will invest $50K at $1.5M Cap into a founder or founders looking to start a new Deep Tech company… If it’s a potential fit, we will schedule one call and give you a quick decision… Are you Technical? Do you have the courage to stand up for what you believe? Are you good at storytelling? Are you a little possessed to build something great?”

Z Fellows

  • Startup fellowship which offers $10K at a $1B valuation cap (or participation without the money), mentorship and guidance, connections, and a 1-week workshop at the end of the program.
  • “Z Fellows are technical builders of all ages working on side projects and startups. We are your first believer. We’ve worked with high school dropouts, college students, and people with full-time jobs across a variety of industries, including consumer, social, enterprise, defense, healthcare, edtech, fintech, gaming, cloud infrastructure, cybersecurity, crypto, AI, ML, climate, biotech, and more. Z Fellows is a one-week startup program. But it really doesn’t end after one week. We continue to help you for the life of your company, and beyond — and so does the ZF alumni community”.
  • Does not require fellows to relocate.

Impetus Grants

  • “Impetus Grants is designed to fund ambitious longevity science that would not happen otherwise. We prioritize speed, conviction, and leverage, so researchers can move fast on ideas that could reshape the field. We provide up to $500k within 3 weeks for scientists to start working on the most important problems in aging biology. To date we have deployed $34M in the field.”
  • “Impetus focuses on work that is too speculative for government funding and too early for company formation.”
  • Offers open field grants (round 4 is targeting total funding of about $5M with up to $500K per awardee) as well as focused grants in areas like “AI-enabled datasets” and “infectious disease and aging”.

Emergent Ventures Grant

  • Philanthropic funding opportunity offered to highly motivated entrepreneurs (and others) with scalable project ideas for meaningfully improving society. Most awardees receive around $10K-$20K, but there are rumors that larger awards have been issued as well. Has a simple online application process centering on a 1500-word proposal.
  • “Launched in 2018, Emergent Ventures is a low-overhead fellowship and grant program that supports entrepreneurs and brilliant minds with highly scalable, ‘zero to one’ ideas for meaningfully improving society. Mercatus Center faculty director Tyler Cowen administers the program”.

Soma Fellows

  • Part of Soma Capital, Soma Fellows is a program that provides funding, mentorship, and network connections for driven entrepreneurs starting disruptive new tech companies.
  • Offers $100K to $1M in uncapped SAFE funding. Might follow on with over $10M for exceptional companies.
  • “Teams have the opportunity to receive $100k to 1m in funding from Soma Capital at the most founder-friendly terms possible. Soma Cap has the firepower to keep supporting you across the full path to IPO and the early stages are just the beginning for us… The program spans several weeks, offering sessions that guide you through the early stages of your entrepreneurial journey and help you build a foundation for scaling lasting companies. The Soma team, leveraging years of experience with top companies of our generation, will become your closest allies in establishing your company’s core and creating a product that impacts billions. The program culminates in a demo day, where founders showcase their products to potential customers, investors, and the community”.
  • No location requirement.

O’Shaughnessy Fellowship

  • Provides $100K to resourceful self-directed people trying to build the future. (No equity taken according to their website).
  • Funds not only founders, but also other people working on exciting projects with high potential to make positive change.
  • 10 fellowships of $100K (plus networking) are offered per year, along with up to 20 grants of $10K plus access to the O’Shaughnessy Ventures network.
  • “The O’Shaughnessy Fellowships is a one year program for researchers, builders and creatives advancing civilization. Twelve Months of pure possibility. No equity. No corporate overlords. No thesis requirements. No committee approvals. Just you, your vision, and the resources to make it real.”
  • “You don’t have to quit your job, but we prefer candidates who are willing to go all in for one year, dedicating a minimum of 40 hours a week to their work during the Fellowships period and ideally north of 60 hours a week.”
  • Does not have a location requirement, though optional gatherings may be hosted.
  • Highly competitive: thousands of people apply for the 10 spots (plus the 20 runner-up grants).
  • “Every applicant is automatically considered for both the $100,000 Fellowship and the $10,000 Grants.”
  • “The fellowships are aimed primarily at individuals. However, we do encourage you to start a company if you are able to.”
  • “If you’ve already started a startup or plan to raise outside investment to build a venture-scale company, please apply to Infinite Adventures – our venture capital arm, using the contact form.” See the O’Shaughnessy Ventures entry in the investor firms section for more.

Amaranth Foundation

  • “Our mission is to engage skilled researchers and support ambitious ideas in the longevity and neuroscience fields. In the past few years, we have donated and committed over $50M to research spanning neuroAI, brain aging, centenarian genetics, and next-gen neurotechnologies.”
  • One can reach out to them to discuss applying for funding through an email on their page.
  • Has a list of longevity priorities listed online referred to as Bottlenecks of Aging. One can submit proposals directly to Bottlenecks of Aging through a link on their page.
  • Sister organization is Starbloom Capital, which invests in longevity biotech, neuroAI, and emerging industries.

Funding for Nonprofits

Astera Residency

  • Offers: “salary of $125,000-$250,000, commensurate with experience, to explore an important problem of their choosing, along with an additional budget for a team and other operational expenses, as necessary; a chance to pitch us and others in our network for longer-term, larger-scale support; medical benefits; and access to substantial compute and programmatic resources”.
  • Focuses on non-proprietary science for public good, so emphasizes nonprofit research programs, generating large datasets, and open-source products.
  • Location in Emeryville California but may offer remote options in the future.
  • Does not permit journal publications on research they fund.

Renaissance Philanthropy

  • Have not found a specific program that offers funding, but they are a philanthropic firm that is likely to offer funding of some kind for nonprofit research organizations.

Training Programs

Frequency Bio

  • 1-week long series of “live virtual sessions covering the fundamentals of finding a co-founder, validating your idea, developing a business model, and raising capital.”
  • Also includes “live virtual and recorded talks from experienced founders.”
  • Positions participants in a community of future founders and helps them stay connected.
  • One applies to join (likely has some level of competitiveness).
  • Hosted by Pillar VC and sometimes others (e.g. MDplus).
  • No geographic requirement.

5050

  • Fifty Years offers a free program called 5050, which provides education on how to transition from a scientific role into operating as a founder.
  • “Over 16 weeks, you’ll work closely with the 50Y team to answer the following questions: Do I have an idea worth pursuing? How do I turn breakthrough research into a startup? Am I addressing a problem with a large enough market? How do I recruit a world-class team? Am I the right person to do it?”
  • Sessions are held in Boston, San Francisco, and remotely. Entire cohort is flown to San Francisco for kickoff and camp weekends.

Investor Firms

SciFounders

  • “We back strong technical leaders who work on world-changing technologies from pre-seed to series A.”
  • “We also run SciFounder Fellowship which comes with up to $1MM to get started and hands-on mentorship from us.”

Fifty Years

  • “We love scientists, engineers, hackers… Fifty Years is a pre-seed and seed focused VC firm. We back founders using technology to solve the world’s biggest problems. We also help start companies. 50Y founders are building massive businesses while solving the world’s most important problems: the climate crisis, disease, connectivity, malnutrition, and more.”
  • Fifty Years sometimes offers Manifest Grants of $25K-$100K for translational research in certain areas. Applications appear to be closed as of the time of this writing.
  • Fifty Years sometimes offers a free program called 5050, which provides education on how to transition from a scientific role into operating as a founder.
  • They have an academic Spinout Playbook resource on their website.

Petri

  • “Petri develops pre-seed companies attacking the world’s largest problems at the frontier of biology and engineering.”
  • “Every Petri company receives access to comprehensive resources and 1:1 coaching to help develop your idea into a company.”
  • “Co-founded and funded by Pillar VC”.
  • Petri emphasizes founder-led companies.

Deep Science Ventures

  • Four key areas: “restorative cultivation, scaling intelligence, the net-zero transition and curative therapeutics”.
  • Curative therapeutics area has four key themes: “effectively leveraging computational approaches to address complexity; developing therapeutics that can compute in-vivo and respond dynamically to the changing internal environment; creating better systems, models and analytics to support therapeutic discovery and development; and a focus on the root cause, including fixing and buffering molecular level damage, fixing broken or unhelpful messaging and signalling pathways, correcting errors at every level of gene expression and modifying the state of cells to drive regeneration.”
  • “Founders joining us have up to 18 months to form a company, are funded for the full duration and get to work with a dedicated sector specialist team. They join to work on opportunities that have been pre-scoped by us and have the chance to form more than one company over the course of their time with us, de-risking the standard founder proposition.”
  • They look for “Ambitious, resilient founders, with a real sense of urgency” and “Deep technical expertise with industry experience” and “Empathetic founders, with a strong ability to persuade through concise storytelling”.

Soma Capital

  • Has a focus on disruptive technologies and highly driven founders, aims to be more founder friendly than other VC firms.
  • “Soma Capital invests in brilliant, fearless teams building Category Kings. We focus on software to automate the world, across any sector and geography that can touch billions of people and push humanity forward”.

1517 Fund

  • A venture capital group that provides very early-stage funding to highly motivated and rebellious outside-the-box entrepreneurs, particularly young dropouts and sci-fi scientists working at the cutting edge of technology.
  • “1517 is a venture capital fund and community supporting college dropouts solving hard problems and deep tech scientists with investment at the earliest stages of their companies. Founded by the cofounders of the Thiel Fellowship, it supports founders across software, hardware, and deep tech verticals and also provides a community to hackers, makers, and scientists from across the world”.

Boost VC

  • Boost VC says they are “the most active Deep Tech investor on the planet” since they “average one deal per week.”
  • “We invest into emerging and frontier categories on the edges of the map… We lead Pre-Seed rounds with $500k checks, and we write $50k Founder Start checks as well.”
  • Emphasizes sci-fi-seeming technologies.

Genesis Fund

  • VC firm which funds early-stage companies.
  • Located in Boston.

O’Shaughnessy Ventures

  • An investment firm focusing on bold early stage founders: “We back tomorrow’s companies & creators before the world knows their names. Whether you’re coding, filming, writing or building, we’re here to provide the resources, support and connections you need. The Mission: Bet early on bold founders with radical ideas.”
  • Also supports book publishing through Infinite Books as well as films and podcasts.
  • Offers the O’Shaughnessy Fellowship of $100,000 (more details in the general funding opportunities section).

Starbloom Capital

  • Invests in deep tech: longevity biotech, neuroAI, and emerging industries.
  • Sister organization to the Amaranth Foundation.

Logan’s List of Entrepreneurship Resources


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PDF version: Logan’s List of Entrepreneurship Resources

I have compiled this list to help myself and others learn about the entrepreneurial landscape and find opportunities for funding. Although experience is the best teacher, these resources can act as a foundation for exploring further avenues of learning. I should note that many (but not all) of these resources are aimed at academic researchers seeking to spin off companies based on new biotechnology inventions. The resources are listed in alphabetical order.

Academic Entrepreneurship How to Bring Your Scientific Discovery to a Successful Commercial Product: book aimed at educating academic entrepreneurs which details important topics like IP, funding, market research, and more. “The pathway to bringing laboratory discoveries to market is poorly understood and generally new to many academics. This book serves as an easy-to-read roadmap for translating technology to a product launch – guiding university faculty and graduate students on launching a start-up company”.

Activate Fellowship: a 2-year fellowship program (full time) for scientists working on startups. Provides guidance on business development, networking, $100K in funding for R&D, $100K per year living stiped, and technical support. “Activate transforms scientists and engineers into founders, empowering them to reinvent the world by bringing their research to market. The two-year Activate Fellowship provides early-stage science entrepreneurs with funding, technical resources, and unparalleled support from a network of scientists, engineers, investors, commercial partners, and fellow entrepreneurs”.

America’s Seed Fund: official website of the U.S. government’s SBIR (Small Business Innovation Research) and STTR (Small Business Technology Transfer) grants. Directs to many more specific resources on how to apply for these grants, what governmental agencies offer them, etc. “America’s Seed Fund awards non-dilutive funding to develop your technology and chart a path toward commercialization. The federal government invests in your solution and gives you the freedom to run your business according to your vision”.

NIH SEED: official website of the NIH’s SBIR and STTR programs which offers resources on funding opportunities, how to apply, entrepreneurial training, etc. “SBIR and STTR grant funding opportunities offer small business entrepreneurs a chance to obtain non-dilutive funding for early-stage research and development. Applications are accepted three times a year… NIH advertises the availability of grant support through notices of funding opportunities (NOFOs), previously referred to as funding opportunity announcements (FOAs)… Researcher-initiated ideas are proposed via the SBIR and STTR Omnibus grant solicitations. These funding opportunities do not specify a topic, though they link to identified topics of interest for each participating awarding component. Most small business applications to NIH are submitted to the Omnibus solicitations”.

Arch Grants: a source of up to $100,000 of funding for St. Louis startup companies which is awarded through an annual startup competition. Improved access to an ecosystem of resources for business development is also provided to winners. “Through our unique and groundbreaking annual Startup Competition model, we provide up to $100,000 in equity-free grants and access to an ecosystem of resources, helping early-stage startups grow and scale”.

WashU Venture Network Follow-on Investments: a funding program of up to $150,000 for companies with ties to Washington University in St. Louis that are also previous Arch Grants winners. “The WashU Venture Network Follow-on Investments is a joint effort between WashU’s Skandalaris Center for Interdisciplinary Innovation and Entrepreneurship and the ‘In St. Louis, For St. Louis’ initiative. It will award up to $150,000 each year to companies with WashU ties that previously have been awarded funding through Arch Grants, the local nonprofit that awards equity-free grants to startups”.

Cake Equity SAFE Notes: a guide from Cake Equity on what a SAFE (Simple Agreement for Future Equity) is and how it works. “What is a SAFE note agreement, how does it work, how is it different from convertible notes, and how to leverage it to raise funds for your startup”.

Charles River: a high-end contract research organization which provides a wide array of services for biotechnology R&D. “Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe accelerate their research and drug development efforts. We deliver what our clients need to improve and expedite the discovery, early-stage development, and safe manufacture of new therapies for patients who need them”.

Charles River AAV Testing: a part of Charles River’s contract research organization which provides GMP characterization and in vitro AAV testing services for gene therapy R&D. “Adeno-associated virus (AAV) is one of the most widely used vectors in gene therapy. Our extensive, in-house AAV testing experience with rigorous characterization and biosafety testing will help ensure that your gene therapy is safe, effective, and regulatory-compliant from preclinical stages to commercialization”.

Charles River Cell Banking: a part of Charles River’s contract research organization which provides cell banking, which can facilitate consistent production biologics for clinical applications. “Cell banking is the foundation of biologics and therapeutics. With decades of experience and over 2,000 cell and/or viral banks successfully produced, our fully integrated CGMP cell bank production, storage, and characterization services will help support your product’s success from R&D through commercial manufacturing”.

Charles River CRADL Vivarium Lab Space: a part of Charles River’s contract research organization which provides animal testing services for biomedical R&D. “Charles River’s Accelerator and Development Lab, provides contract vivarium lab space with built-in animal husbandry, veterinary care, operations management, and IACUC protocol support to give you greater speed, flexibility, and control over your mice and rat in vivo pharmacology studies”.

Charles River GMP AAV Production Service: a part of Charles River’s contract research organization which provides GMP-grade AAV manufacturing services. “As a trusted CDMO partner for AAV production services, our multi-disciplinary teams provide the experience and dedication to quality that you need to scale up your AAV gene therapy project into a patient-ready product. Leverage the nAAVigation® AAV manufacturing platform to bolster your program with all-important predictability, guidance, and reduced time to clinic”.

Cooley GO: a website with articles about business concepts for entrepreneurs at various stages of developing startups. “At Cooley, we want to give you the information you need to build a great company – easily accessible and from the most trusted source”.

Cooley GO: What You Should Know About SAFEs: an article from Cooley GO on the SAFE (Simple Agreement for Future Equity) investment mechanism. “A SAFE is an investment instrument that converts the holder’s value into equity of the issuer upon certain triggering events”.

Curie.Bio: a therapeutics-focused VC firm that provides funding at the seed and series A stages as well as extensive guidance and assistance to scientific founders building biomedical companies. They offer a ‘co-pilot’ program to guide founders towards optimal therapeutic targets, a network of CROs, and more. Has a low acceptance rate (~1%) for funding. “We built Curie.Bio to free the founders. Curie.Bio significantly improves your ability to create impactful medicines while minimizing long-term dilution. Our unparalleled team and capital-efficient model provide you with immediate access to the industry’s top drug hunters, operators, and R&D services from day one”.

Emergent Ventures Grant: a philanthropic funding opportunity offered to highly motivated entrepreneurs (and others) with scalable project ideas for meaningfully improving society. Most awardees receive around $10K-$20K, but there are rumors that larger awards have been issued as well. Has a simple online application process centering on a 1500-word proposal. “Launched in 2018, Emergent Ventures is a low-overhead fellowship and grant program that supports entrepreneurs and brilliant minds with highly scalable, ‘zero to one’ ideas for meaningfully improving society. Mercatus Center faculty director Tyler Cowen administers the program”.

Experiment: a crowdfunding organization that provides small grants to scientific projects if donations meet a user-defined goal amount. “Experiment is an online platform for discovering, funding, and sharing scientific research… Creators never give up any ownership of their work to Experiment or backers. You keep 100% ownership and control over your work”.

Fifty Years: a VC firm focused on funding early-stage deep tech companies with technical founders. They also provide guidance to help technical/scientific founders build companies. “Fifty Years is a pre-seed and seed focused VC firm. We back founders using technology to solve the world’s biggest problems. We also help start companies. 50Y founders are building massive businesses while solving the world’s most important problems: the climate crisis, disease, connectivity, malnutrition, and more”.

Spinout Playbook: a guide from Fifty Years which provides advice for spinning companies out from inventions in academic laboratories. “We’ve seen negotiations with tech transfer offices (TTOs) take so long that founders burned out, teams lost momentum, and investors walked away. We’ve seen TTOs introduce terms that hurt the startup’s ability to raise capital. We’ve seen so many exotic term combinations that we wondered: how are founders supposed to make sense of it all? So we made this Spinout Paybook to help aspiring scientist founders make sense of the process”.

Manifest Grants: a fast grants program run by Fifty Years which offers pre-seed funding to scientists working on translational ideas. Applications are closed as of 2/2/2025 but may reopen at some point. “Manifest Grants is a fast grants program that awards $25K – $100K to scientists to accelerate their most ambitious ideas to solve the world’s biggest problems. We focus on translational research. The applications are max 2 pages and you get a decision within 21 days. No IP is taken. Are you an academic scientist working on a translational research idea for solving a big problem? Follow us on X (Twitter) to keep an eye out for updates on our grants programs. Applications are closed at the moment”.

Hevolution Foundation: a Saudi Arabian organization with a mission to treat aging and improve healthspan. It has an annual budget of $1B and provides a variety of grants and opportunities (for both translationally minded academics and companies). “Hevolution Foundation is the first non-profit to pursue age-related therapeutic breakthroughs with a commitment to funding global scientific discovery, and investing in private companies and entrepreneurs who are dedicated to advancing aging science. Through the acceleration of science, we can decelerate aging and its consequences”.

How to Start a Life Science Company: A Comprehensive Guide for First-Time Entrepreneurs: a book which provides a helpful primer on important steps for forming, growing, and running life sciences companies. “This comprehensive guide takes first-time entrepreneurs through every step of founding a life science company. It covers all the business basics that we aren’t taught in science and engineering courses”.

How to Build a Biotech: part of Celine Halioua’s blog where she provides educational writeups on a variety of topics for biotechnology entrepreneurship. “The Summer of 2019, I (Celine) gave a series of lectures to Longevity Fund’s Venture Fellows on the basics of building a biotechnology company. This is the write up of those lectures, with some additions by Laura Deming & myself (Celine)”.

Basics of Life Science Patents: great educational blog post by Celine Halioua providing an introduction to what one should know about IP protection for biotechnology. “There are three broad categories of patents: utility, plant, and design patents. Generally, biotech patents are utility patents, like the vast majority (>90%) of patents. Utility patents are enforceable for 20 years, beginning from date of earliest filing. This ticker starts when you file a provisional patent, despite the fact that the patent may not be granted for years after this filing”.

Venture Capital for Bio 101: excellent educational blog post by Laura Deming and Celine Halioua which explains the process, challenges, and strategies of seeking VC funding for biotechnology startups. “Venture capitalists are investors who specifically invest in high risk, high reward companies. Venture capitalists invest capital in your company in exchange for equity, in the hope that the equity is worth significantly more in the future. This post will cover how to find and convince such a person to swap money for equity in your new company”.

Investopedia: an online encyclopedia with numerous detailed articles covering topics in business, entrepreneurship, and investing. “Investopedia was founded in 1999 with the mission of helping people improve their financial outcomes”.

Common Stock: What It Is, Different Types, vs. Preferred Stock (Investopedia article): an article on Investopedia that discusses the concepts of common stock and preferred stock. “Common stock is not just a piece of paper—or, these days, a digital entry—but a ticket to ownership in a company. When you hold common stock, you get to weigh in on corporate decisions by voting for the board of directors and corporate policies”.

Par Value of Stocks and Bonds Explained (Investopedia article): an article on Investopedia that discusses the concept of par value for stocks and bonds. “Par value, also known as nominal or original value, is the face value of a bond or the value of a stock certificate, as stated in the corporate charter. Par value is required for a bond or a fixed-income instrument and shows its maturity value and the dollar value of the coupon, or interest, payments due to the bondholder”.

J.P. Morgan Healthcare Conference: an important event where biomedical entrepreneurs network, negotiate, and make deals with investors as well as form other kinds of partnerships. “This premier conference is the largest and most informative health care investment symposium in the industry which connects global industry leaders, emerging fast-growth companies, innovative technology creators and members of the investment community”.

LegalZoom: offers services to help handle the legal paperwork associated with starting and maintaining a business. “A tech company dedicated to making legal help accessible to all… launched 10 online services, focusing on estate planning, business formation, and intellectual property protection… easier, and less expensive way to get legal help… an independent network of attorneys so our customers could get personalized legal advice – without having to leave home”.

Business formation: offers packages for helping to incorporate businesses and work through the legal process of doing so. “Choose your business type… Answer a few questions… We’ll complete and file your paperwork”.

List of Biotechnology Companies to Watch: my own list of innovative biotechnology companies that are making an impact. Includes links to the company websites as well as key facts about each. May be useful for exploring landscapes of competitors and potential partners. “I created this list of organizations… to serve as a resource to help people learn about and keep track of key biotechnology companies. Some of these are emerging startups, some are established giants, and some provide useful services. Some notable nonprofit organizations are included as well”.

LongeVC Venture Fellowship Program: a remote 6-month program that guides ambitious graduate students and postdocs through learning about business strategy. “This program offers a unique opportunity to collaborate closely with our investment team, assisting in evaluating potential investments, participating in company pitches, and developing strategic initiatives. Fellows will also have the chance to network with industry experts and gain exposure to cutting-edge fields such as drug discovery and development, computational and synthetic biology, and genomic medicine. This is a part-time, remote, 6-month paid fellowship, with the potential for extension based on performance and mutual interest”.

NSF I-Corps: a program from the U.S. government that helps guide small businesses and make them more successful. Teams can apply for the program and then will be taken through an intensive experiential learning program to develop their company. “Launched to support NSF’s mission through experiential learning using the customer discovery process – allowing teams to quickly assess their inventions’ market potential. I-Corps prepares scientists and engineers to extend their focus beyond the laboratory to increase the economic and societal impact of NSF-funded and other basic research projects”.

I-Corps hubs: a program wherein I-Corps provides local training at certain locations and in partnership with certain institutions to help new startup teams learn about entrepreneurship. “Bring together institutions of higher education within a distinct geographical region to collaborate and deliver a standardized curriculum. The curriculum explores the commercial potential of deep technologies with members of the scientific community and other interested parties in the Hub’s region”.

I-Corps teams: the program that I-Corps uses to guide early startup teams through the process of developing their business. “Supports teams of scientists and engineers to explore the commercial potential of technologies developed in university laboratories through a standardized entrepreneurial training program”.

Nucleate: a student-led organization which identifies, educates, connects, and empowers academic biotechnology entrepreneurs to create and run startups. George Church, Tom Kalil, and Pamela Silver are some of the advisors. “Nucleate is a student-led organization that represents the largest global community of bio-innovators”.

Nucleate Activator: a six-month entrepreneurship program that equips academic biotechnology founders with the skills and connections for successful business development. “Activator is a six-month, equity-free cohort program designed for academic biotech founders. Its curriculum has served more than 100 life sciences ventures that have raised over $190 million in venture funding. Participating teams refine their scientific discoveries into biotech venture theses and train under Nucleate’s unparalleled network, rigorous curriculum, funded fellowships, legal support, and highly subsidized perks. Activator culminates in a final pitch showcase before world-renowned judges”.

Nucleate Operationalizing Your Therapeutics Spinout Playbook: an educational booklet which provides guidelines for academic biotechnology entrepreneurs on how to create and operate startup companies. “Successfully transitioning academic research to real world applications is a significant challenge for life science entrepreneurs. The goal of this playbook is to provide a comprehensive guide for academic founders, covering essential aspects of company creation and operational strategies. In partnership with Alexandria LaunchLabs and Curie.Bio”.

Petri: a Boston venture firm which provides mentorship, resources, and funding for biotechnology founders. “Petri is co-founded by a group of leaders who have deep experience building ideas into iconic companies, and academics who are driving foundational science in bioengineering. We believe the future of biotech lies in supporting the next-generation of founders who will lead us there. Petri surrounds founders with the support they need to build world-class teams, grow as leaders, develop intellectual property, find customers, and raise capital”.

O’Shaughnessy Fellowship: a remote program that offers $100K to ten researchers, builders, and creatives to work on boldly innovative projects (it appears early-stage companies might be eligible, although the fellowship is primarily aimed at individuals). Also offers $10K plus networking opportunities via the O’Shaughnessy grants program to twenty more people working on exciting projects. “This is the O’Shaughnessy Fellowships & Grants. A one-year program that unites the world’s most bold and undiscovered researchers, builders and creatives to find, build and spread new ideas. In just two years, we’ve scoured over 140 countries to find and fund 55 extraordinary innovators, leading to six companies & non-profits, five documentaries, >2.2 billion views on YouTube, and the blossoming of numerous scientific, creative, and technological projects”.

O’Shaughnessy Infinite Adventures: the investment arm of O’Shaughnessy Ventures which offers funding, networking, and support. They are mostly looking for investment opportunities of $1M+, but they sometimes invest <$1M. “Conventional VC firms often only provide funding and some advice. We are a multidimensional investment company that not only offers capital, but also amplifies your story through our ever-growing media network”.

Pillar VC: a VC firm that focuses on backing transformative technology company founders at early stages. They have a particular focus on academic spinoff companies. Has a team of experienced CEOs to provide guidance to new founders. “The term VC itself evokes an evil empire — the dark side — a painful lack of alignment between investors and entrepreneurs. In a business where trust is paramount, the dark side created a world that put us at odds with those we needed to trust most. Pillar is fixing that”.

Pillar VC Moonshot: a startup competition for academic spinoffs which awards at least two winners $250K SAFEs and one winner a $1M SAFE. “At least one member of your Founding Team must be a university undergraduate, grad student, postdoc or faculty member. Whether you have an idea for an industry-leading company or a groundbreaking technology, all ideas are open for consideration”.

SciFounders: an investment group that funds founders who have technical backgrounds. Offers a fellowship that provides up to $1M as well as mentorship to technical founders working on innovative early-stage startups. “We back strong technical leaders who work on world-changing technologies from pre-seed to series A. We also run SciFounder Fellowship which comes with up to $1MM to get started and hands-on mentorship from us”.

Soma Capital: a non-traditional VC firm with a focus on disruptive technologies and highly driven founders, aims to be more founder friendly than other such firms. “Soma Capital invests in brilliant, fearless teams building Category Kings. We focus on software to automate the world, across any sector and geography that can touch billions of people and push humanity forward”.

Project 31: a non-dilutive pre-seed funding opportunity that Soma Capital offers to help kick off the beginnings of new startups. “An initiative by Soma Capital to empower today’s pioneers with $11,111, a vast network of mentors, and the infrastructure you need to materialize ambitions”.

Soma Fellows: a program that provides funding, mentorship, and network connections for driven entrepreneurs starting disruptive new tech companies. “Teams have the opportunity to receive $100k to 1m in funding from Soma Capital at the most founder-friendly terms possible. Soma Cap has the firepower to keep supporting you across the full path to IPO and the early stages are just the beginning for us… The program spans several weeks, offering sessions that guide you through the early stages of your entrepreneurial journey and help you build a foundation for scaling lasting companies. The Soma team, leveraging years of experience with top companies of our generation, will become your closest allies in establishing your company’s core and creating a product that impacts billions. The program culminates in a demo day, where founders showcase their products to potential customers, investors, and the community”.

So You Want to Start a Biotech Company: an article published in Nature Biotechnology which provides an overview of some of the key steps, challenges, and strategies needed for starting a biotechnology company. “Commercializing research is fraught with pitfalls, but a thoughtful checklist can ensure you set off on the right path and give your fledgling business the best chance of success”.

Thrive Capital: an investment firm focusing on technology companies including some biotechnology companies (esp. AI for biology). “Thrive Capital is an investment firm that builds and invests in internet, software, and technology-enabled companies”.

Trailblazer List: a resource which lists a variety of highly impactful companies across different fields. May be useful for exploring landscapes of competitors and potential partners. “There are endless meaningful problems. Join a team building the future. Make science-fiction real. Explore something different. Discover deep-tech companies”.

Veterinary Innovation Program (FDA): an FDA-hosted program that offers regulatory guidance (as well as enhanced review efficiency) to companies developing genetically engineered animal, tissue, or cell products. “The FDA Center for Veterinary Medicine’s (CVM) Veterinary Innovation Program (VIP) is for certain intentional genomic alterations (IGA) in animals and animal cells, tissues, and cell- or tissue-based products (ACTPs). The goal of the VIP is to facilitate advancements in development of innovative animal products by providing greater certainty in the regulatory process, encouraging development and research, and supporting an efficient and predictable pathway to market for ACTPs and IGAs in animals”.

Y Combinator Guide to Seed Fundraising: a publicly available set of recommendations from Y Combinator on concepts, terminology, and best practices for startup seed round fundraising from VCs, angel investors, etc. “This brief guide is a summary of what startup founders need to know about raising the seed funds critical to getting their company off the ground”.

Y Combinator SAFE documents: publicly available legal SAFE (Simple Agreement for Future Equity) documents used by Y Combinator. Several versions with different conditions are available. “Y Combinator introduced the safe (simple agreement for future equity) in late 2013, and since then, it has been used by almost all YC startups and countless non-YC startups as the main instrument for early-stage fundraising”.

Z Fellows: a startup fellowship which offers $10K at a $1B valuation cap (or participation without the money), mentorship and guidance, connections, and a 1-week workshop at the end of the program. Does not require fellows to relocate. “Z Fellows are technical builders of all ages working on side projects and startups. We are your first believer. We’ve worked with high school dropouts, college students, and people with full-time jobs across a variety of industries, including consumer, social, enterprise, defense, healthcare, edtech, fintech, gaming, cloud infrastructure, cybersecurity, crypto, AI, ML, climate, biotech, and more. Z Fellows is a one-week startup program. But it really doesn’t end after one week. We continue to help you for the life of your company, and beyond — and so does the ZF alumni community”.

50 Biotech Seed & Angel Investors to Check Out in 2024: an article listing 50 groups/organizations that invest in early-stage biotechnology companies and providing some information about each. “In this blog post, we’ll explore the landscape of biotech seed and angel investors in 2024, highlighting key players who are shaping the future of this dynamic industry”.

100 Plus Capital: an investment group that focuses on funding companies that could improve human longevity. “100 Plus Capital invests in companies positively impacting human longevity. This can be directly targeted (for example, anti-aging companies) or broader reaching (clean food and water companies). If you are working on extending human healthspan, we are interested in hearing your ideas”.

1517 Fund: a venture capital group that provides very early-stage funding to highly motivated and rebellious outside-the-box entrepreneurs, particularly young dropouts and sci-fi scientists working at the cutting edge of technology. “1517 is a venture capital fund and community supporting college dropouts solving hard problems and deep tech scientists with investment at the earliest stages of their companies. Founded by the cofounders of the Thiel Fellowship, it supports founders across software, hardware, and deep tech verticals and also provides a community to hackers, makers, and scientists from across the world”.

6 Steps to Incorporating Your Business: a simple webpage published by the U.S. Chamber of Commerce that provides an overview of the business incorporation process and options. “If you are considering incorporating your business, it simply means you are creating an entity that is legally separate from you. A corporation can own property and sign contracts, it can be sold and carry on without your involvement, and, if it goes bankrupt, you are not held personally liable. While every state handles the process a bit differently, there are six basic steps you should keep in mind”.