My name is Logan Thrasher Collins and I make science fiction into reality. I am a futurist, synthetic biologist, author, and innovator. When I was 16, I invented a new antimicrobial protein, OpaL (Overexpressed protein aggregator Lipophilic). I next developed a bacterial conjugation delivery system for the gene encoding OpaL. My synthetic biology research has been published as a first-author journal article in ACS Biochemistry: “Design of a De Novo Aggregating Antimicrobial Peptide and a Bacterial Conjugation-Based Delivery System.” If you cannot access the full text, please use the following local file instead. In addition, my synthetic biology research has been recognized at numerous venues including TEDxMileHigh, the Intel International Science and Engineering Fair (ISEF), the International BioGENEius Challenge at the BIO International Convention, and at the American Society for Microbiology General Meeting. At Intel ISEF 2014, my synthetic biology research won 1st place in microbiology and best of category in microbiology ($8,000) as well as the Dudley R. Herschbach award. The latter included a trip to take part in the Nobel prize ceremonies via the Stockholm International Youth Science Seminar (SIYSS). As part of the honors at Intel ISEF, a minor planet was officially named Logancollins.
I am currently a PhD candidate in biomedical engineering at Washington University in St. Louis where I am working on applying my background in synthetic biology and protein engineering to develop superior adenoviral gene therapy platforms in the laboratory of Professor David Curiel. I have made progress towards engineering a novel gene therapy delivery system and have received an NIH Ruth L. Kirschstein Institutional National Research Service Award grant to support my research. I helped obtain another $500,000 in funding for the project by contributing centrally to the writing of a grant for the Collaboration Opportunity Fund within the Somatic Cell Genome Editing Consortium. The funding will be split between the Curiel laboratory and the laboratories of our collaborators at Baylor University and Rice University. In conjunction with this research, I wrote a first-author review journal article which has been published in ACS Nano: “Synthetic Biology Approaches for Engineering Next-Generation Adenoviral Gene Therapies.” If you cannot access the full text, please use the following local file instead.
I am also the Chief Technology Officer (CTO) at Conduit Computing. At Conduit, I led a supercomputing project which allowed visualization of how the constituent proteins of SARS-CoV-2 work to construct whole viruses. For this research, I am the lead author (and the corresponding author) on a journal article which has been published in the ACS Journal of Physical Chemistry Letters: “Elucidation of SARS-Cov-2 Budding Mechanisms through Molecular Dynamics Simulations of M and E Protein Complexes” (open access). My and my team’s paper gives mechanistic explanations of SARS-CoV-2 budding and provides a foundation for the development of drugs which might treat COVID-19 and similar diseases. The story of this research starts at the beginning of the pandemic when my original grant proposal was accepted by the COVID-19 HPC Consortium. The consortium is a U.S. government initiative which brought together supercomputer resources from academia and industry to help fight the COVID-19 pandemic. My team was matched with Frontera, the 4th most powerful supercomputer in the world at the time we were matched. We used this supercomputer to implement our simulations of coronavirus budding. I was featured by a major news site called HPCwire as well as by Re.engineer Magazine for my work leading this project.
Also at Conduit, I am leading the design of a novel diagnostic for infectious disease (including SARS-CoV-2) which we call nanoSPLASH. People will be able to use nanoSPLASH at home without the aid of a clinician and nanoSPLASH will provide a colorimetric diagnosis in less than one hour. Since nanoSPLASH will use a nucleic acid sequence-based recognition method, it will be very easy to modify for diagnosis of any kind of infectious disease. Conduit is now raising funding to develop, manufacture, and distribute nanoSPLASH. I am listed as the primary inventor of nanoSPLASH on a provisional patent. We are currently collaborating with contract research organizations to construct and validate a prototype. Some early experiments have been performed, though a full prototype is not yet ready.
I have also worked in neuroengineering and connectomics. I developed a nanotechnology-based contrast agent for imaging brain tissue via x-ray microtomography. I received a $26,000 award to develop this technology (through the Beckman Scholars Program) and I acquired some promising proof-of-concept data. I presented this research at the Society for Neuroscience conference and the Beckman conference. I also wrote a sole-author editorial journal article on insect brain emulation which has been published in Biological Cybernetics: “The case for emulating insect brains using anatomical ‘wiring diagrams’ equipped with biophysical models of neuronal activity.” If you cannot access the full text, please use the following local file instead. This paper proposes creating biologically realistic simulations of insect brains and details a possible path towards that goal. The international organization NeuroTechX has published my timeline of major breakthroughs in neurotechnology from 2005-2018 (Global Highlights in Neuroengineering). For an updated and expanded version of my timeline, visit Global Highlights in Neurotechnology, Connectomics, and Brain Simulation: 2005 to 2019.
In addition to research, I write science fiction and sci-fi poetry. For me, writing is both intrinsically rewarding and helps to stimulate my imagination and shape my scientific endeavors. My writing fuels my science and my science fuels my writing.
My published sci-fi poems include The Sonata Machine (Andromeda Spaceways Magazine), Neuraweb (Abyss & Apex Magazine), Neuva Shikaga (Altered Reality Magazine), Gorgeous Geometries (Altered Reality Magazine), cyberjinn (Altered Reality Magazine), Glimmerglimpse (Mithila Review), Electrocologies (Mithila Review), and Foreversong (Silver Blade). Neuraweb has been nominated for the Pushcart Prize and the Rhysling Award. In addition, The Sonata Machine has been reprinted in Altered Reality Magazine.
My published short fiction pieces include Events after the life of Edgar (The Centropic Oracle), Honeybee and the Blot (Theme of Absence), Relinquish / Metamorph (365tomorrows), Queen of the Universe (Aphelion), Mahabbah (After Dinner Conversation), Oddballs (Across the Margin), and The Incandescence of Her Simulacrum (Zooscape). In addition, my poetry and fiction have been recognized in student-run literary magazines as well as (longer ago) the Scholastic Art and Writing Competition. I have written and am working on numerous other science fiction pieces.
I am an avid autodidact. I have independently studied a wide array of topics such as molecular biology and genetics, applied probability, biochemistry, microbiology, digital artwork, endocrinology, protein engineering, MATLAB and Python, science fiction, CRISPR biotechnology, graph theory, insect neuroscience (i.e. Drosophila and bees), computational neuroscience, quantum mechanics, topology, medicinal chemistry, nanotechnology (e.g. nanoparticle superlattices and upconversion nanoparticles), techniques in microscopy (i.e. light-sheet and two-photon), optics and microscopy, digital electronics, Lagrangian and Hamiltonian mechanics, biotechnology, and many more.
My personal philosophy most closely aligns with transhumanism, positive existentialism, rational romanticism, scientism, liberal feminism, socialistic capitalism, technogaianism and bright green environmentalism, technological utopianism, technoprogressivism, physicalist panpsychism, and kindness.
In the long term, I plan to gain a position as a professor at a major research university. I also plan to collaborate with industry to bring my research towards its real-world applications. My primary goals are to positively impact people’s lives with my inventions and discoveries and to help protect the long-term future of humanity.
I am actively working towards making the future the best that it can be. Get your head in the clouds, the future is only limited by the imagination!